Clinic-in-the-Loop
Summary
The article argues that clinical trials should be viewed as engines of discovery rather than mere validation steps, advocating for the Clinical Trial Abundance framework to accelerate learning from trials. It uses CAR-T therapy to illustrate how iterative, data-rich experiments can overcome early design failures, and highlights regulatory and manufacturing bottlenecks that inflate costs. It also proposes policy and technological changes to enable faster, more informative in-human trials.