Sprint or marathon? Aging muscle stem cells shift from rapid repair to long-term survival
Summary
A UCLA study reports that aging muscle stem cells accumulate more of the NDRG1 protein, dampening rapid repair but increasing long-term survival by suppressing mTOR signaling. Blocking NDRG1 restores quick repair in old cells but lowers their long-term survival, illustrating a trade-off between regeneration speed and persistence in aging tissue.