Perturb-MARS: Reading mouse experiments through a human lens
Summary
Noetik presents Perturb-MARS, a platform that merges multiplexed in vivo perturbations in mice (Perturb-Map) with a human-centered foundation model (TARIO-2) to translate animal data into human biology readouts. This approach preserves spatial tumor architecture, enabling scalable exploration of drug combinations and patient stratification by mapping mouse perturbations into human-centric space. The article outlines how Perturb-Map works, why it offers advantages over traditional animal studies, and how the integration with TARIO-2 yields actionable insights with potential clinical implications.