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A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms

Quality: 9/10 Relevance: 9/10

Summary

Nature Methods reports MOSAIC, a modular, adaptive optical microscope enabling multiple imaging modalities (LLSM, OI, 3D-SIM, ISM, TPM) with adaptive optics and rapid reconfiguration. The paper emphasizes cost reduction, correlative multimodal imaging, and large-scale data handling with GPU pipelines, and discusses implications for data generation and AI-assisted analysis.

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